Stimulation in nonfailing and failing human ventricularPrenalterol (131-agonist), denopamine ($1-agonist), and zinterol ($2-agonist) were partial agonists of adenylate cyclase (AC) stim-ulation in human ventricular myocardium obtained from nonfailing chambers whose 191/192 receptor subtype...
� 2-adrenergic receptor signaling acts via no release to mediate achinduced activation of atp-sensitive k � current in cat atrial myocytes... 1 �M zinterol ( � 2-AR agonist) also increased I Ca,L and mediated ACh-activated I K,ATP....
Multiple signalling pathways involved in β(2)-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells... The β-AR agonists, zinterol (β(2)-AR) and (−)-isoprenaline, increased cAMP accumulation in a concentration-dependent manner (pEC(50)=9.1±0.02...
Murine ventricular l-type ca(2+) current is enhanced by zinterol via β(1)-adrenoceptors, and is reduced in tg4 mice overexpressing the human β(2)-adrenoceptor... The β(2)-AR signalling cascade was activated either with the β(2)-AR selective agonist zinterol (myocytes from wild-type mice), or by spontaneously active, unoccupied β(2)-ARs (myocytes from TG4 mice with 435 fold overexpression of human β(2)-ARs)....
