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zacopride

santé / chimie - iate.europa.eu
La présente invention concerne l'utilisation de (R)-zacopride ou d'un sel de ce dernier dans la préparation d'un médicament destiné au traitement de l'apnée du sommeil.

The present invention relates to the use of R-zacopride or a salt thereof in the manufacture of drugs intended for the treatment of sleep apnea.

santé - wipo.int
The preventative and curative effects of zacopride on mi- induced ventricular arrhythmias in anesthetized rats in vivo.... Zac, zacopride, at 15 μg/kg....
général - core.ac.uk - PDF: figshare.com
Representative transmembrane potentials (tmps) showing the effects of zacopride on the rmp (a) and ap (b) in rat ventricular myocytes under hypoxic conditions.The right panel of B shows the statistical analysis of APD changes in response to zacopride (1 μmol/L) or zacopride (1 μmol/L) plus BaCl2 (1 μmol/L)....
Zacopride and brl 24924 induce an increase in eeg-energy in rats.... The substituted benzamides, zacopride and BRL 24924 induced dose-dependent increases of the total EEG-energy of rats when applied intracerebroventricularly (i.c.v.)...
Agonist effects at putative central 5-ht(4)receptors in rat hippocampus by r(+)-zacopride and s(-)-zacopride - no evidence for stereoselectivity... In the present study the effect of R(+)- and S()-zacopride, administered intra-cerebroventricularly, on different frequency bands of the EEG was investigated....
The enantiomers of zacopride: an intra-species comparison of their potencies in functional and anxiolytic models.... The 5-HT3 receptor antagonist, zacopride, and its enantiomers, R(+)-zacopride and S(-)-zacopride, were examined in three pharmacological models: (i) 5-HT-induced depolarization of the mouse isolated vagus nerve...


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