Quantitative structure-pharmacokinetic relationship modelling: apparent volume of distributionThe purpose of this study was to develop a quantitative structure-activity relationship (QSAR) for the prediction of the apparent volume of distribution (Vd) in man for a heterogeneous series of drugs....
Saturable disposition of taurine in the rat cerebrospinalABBREVIATIONS: V1, apparent volume of distribution of the CSF; CLIk, bulk flow clearance; CL1, transfer clearance from the brain tissue to the CSF; VmRA, apparent maximal velocity; KM, the Michaelis-Menten...
Calculated pharmacokinetic parameters t1/2 = half-life, vd/f = apparent volume of distribution, cl/f = apparent clearance....tissue.Calculated pharmacokinetic parameters t1/2 = half-life, Vd/F = apparent volume of distribution, Cl/F = apparent clearance.
Time varying apparent volume of distribution and drug half-lives following intravenous bolus injections.We present a model that generalizes the apparent volume of distribution and half-life as functions of time following intravenous bolus injection....