Laboratory exposure (where there is a potential exposure to Variola virus
Laboratory exposure (where there is a potential exposure to Variola virus
Detection of Variola virus nucleic acid in a clinical specimen followed by sequencing
Detection of Variola virus nucleic acid in a clinical specimen followed by sequencing
These compounds are particularly useful as inhibitors of vaccinia virus and variola virus replication and/or for the treatment of vaccinia virus and variola virus infection.
Isolation of smallpox (variola virus) from a clinical specimen followed by sequencing (designated P4 laboratories only
Naturally occurring variola virus has been eradicated from the planet.
Variola virus is relatively stable in the natural environment.
In 1798 Jenner published his findings with this title – I like this title – Inquiry into the Cause and Effects of the Variola Vaccine – the variola virus is the smallpox virus.
This means that the variola virus is no longer present in the world.
It is caused by variola virus, which is a member of a larger pox family of viruses.
The variola virus exists legitimately in only two laboratories in the world.
The nucleoside compounds may be administered alone or in combination with other agents active against orthopoxvirus infection, in particular against vaccinia virus or variola virus infection.
It was certified that the Variola virus have been eradicated from the world’s population in 1980’s and this smallpox vaccination was stopped completely.
Nevertheless, variola virus remains a risk as routine vaccination is no longer undertaken.
The possession and use of variola viruses are restricted to the WHO collaborating centers(Footnote 27).
There are no animal reservoirs of variola virus and the last human case occurred in 1978.
For example, the World Health Organization announced in December 1979 that the world was free of variola virus.
According to the CDC, “these scabs and the fluid found in the patient’s sores also contained the variola virus.
these scabs and the fluid found in the patient’s sores also contained the variola virus.
What is described is a recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, containing foreign DNA from herpes virus.
Recombinant fowlpox virus or related avian poxvirus is characterised by the inclusion of foreign DNA in the virus genome.
The recombinant viruses can be NYVAC or ALVAC recombinant viruses.
An example for such a poxvirus is a Modified Vaccinia virus Ankara (MVA).
Organism Identity: PROSTVAC-V (modified Vaccinia virus), PROSTAC-F (modified Fowlpox virus) and TBC-FPV (Fowlpox virus vector).
In a preferred embodiment, the pathogenic microorganism is smallpox virus or vaccinia virus.
The invention further relates to homology vectors which produce recombinant swinepox viruses by inserting foreign DNA into swinepox viral DNA.
Because of its similarities to the smallpox virus, the antibodies produced against this virus are also expected to protect against smallpox.
Vaccinia virus is the prototypic member of the Orthopoxvirus genus, which also includes variola and monkeypox virus.
Methods and compositions for the use of vaccinia virus or other poxviruses as vectors for expression of foreign genes.
The chimeric gene is flanked by DNA from a non-essential region of poxvirus genome to provide sites for in vitro homologous recombination in cells previously infected with a genus of poxvirus.
It should be known that the vaccinia virus is similar to the smallpox virus.
It can also be cloned in a poxvirus which is used to transfect mammalian cells.
The vaccine vectors include poxvirus, herpes virus or adenovirus, and the lymphokine may be an interleukin or gamma-interferon.
Thus, a smallpox virus and a vaccinia virus vector producing no B5R gene product having the normal function by reverse mutation are provided.
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