Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: modulation of p-glycoprotein 170 and targeting of the transferrin receptor... Combining cytostatic agents that are p-gp substrates with inhibitors of p-gp like valspodar is a new approach to overcome the BBB....
A double blinded, placebo-controlled pilot study to examine reduction of cd34+/cd117+/cd133+ lymphoma progenitor cells and duration of remission induced by neoadjuvant valspodar in dogs with large b-cell lymphoma [version 2; referees: 2 approved]... We examined whether valspodar, a selective inhibitor of the ATP binding cassette B1 transporter (ABCB1, a.k.a.,...
Phase i study of pegylated liposomal doxorubicin and the multidrug-resistance modulator, valspodarValspodar, a P-glycoprotein modulator, affects pharmacokinetics of doxorubicin when administered in combination, resulting in doxorubicin dose reduction....
Valspodar-modulated chemotherapy in human ovarian cancer cells sk-ov-3 and mdah-2774... Valspodar is the second generation P-glycoprotein 1 modulator capable of reversing multidrug resistance in different cancers....
