For novel vehicles, a sham-treated control group should be included in addition to a vehicle control group.

If a pre-study of a test chemical formulated in a vehicle reveals no toxicity, it follows that the vehicle is non-toxic at the concentration tested and this vehicle control should be used.

The toxicity of derivative 'A' was determined to be even lower than vehicle control (ALT and AST markers).

When using the pooled treatment group approach, show the mean/median DPM and the mean SI for each dose group compared against the concurrent VC group.