Dictionnaire français - anglais

trimétrexate

santé / chimie - iate.europa.eu
L'invention concerne une nouvelle composition d'ascorbate de trimétrexate, des compositions contenant ascorbate de trimétrexate, ainsi que des compositions contenant trimétrexate et acide ascorbique.

This invention is directed to the novel composition of matter trimetrexate ascorbate, to compositions comprising trimetrexate ascorbate, and to compositions comprising trimetrexate and ascorbic acid.

santé - wipo.int
Elle concerne, de plus, de nouveaux procédés servant à préparer des composés stables de base libre de trimétrexate, y compris monohydrate de trimétrexate cristallin.

The present invention further provides novel methods of producing stable trimetrexate free base compounds, including crystalline trimetrexate monohydrate.

chimie - wipo.int
L'invention concerne des formes stables à la chaleur de 2,4-diamino-5-méthyl-6-[(3,4,5-triméthoxyanilino)méthyl]quinazoline ou trimétrexate.

The present invention provides for thermally stable forms of 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline, or trimetrexate.

chimie - wipo.int
Elle concerne, de plus, des procédés servant à stabiliser trimétrexate contre la dégradation provoquée par la chaleur, la lumière, l'oxygène ou l'eau.

The invention is further related to methods of stabilizing trimetrexate to degradation caused by heat, light, oxygen, or water.

santé - wipo.int
Trimetrexate with leucovorin versus trimethoprim-sulfamethoxazole for moderate to severe episodes of pneumocystis carinii pneumonia in patients with aids: a prospective, controlled multicenter investigation of the aids clinical trials group protocol 029/0Trimetrexate is a powerful inhibitor of the dihydrofolate reductase of Pneumocystis carinii....
santé - core.ac.uk - PDF: jid.oxfordjournals.org

Publications scientifiques

Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexate.Trimetrexate, a highly lipid-soluble quinazoline antifolate now undergoing trials as an anticancer agent, was found to be a potent inhibitor of the dihydrofolate reductase (DHFR)...
général - core.ac.uk - PDF: www.pubmedcentral.nih.gov
Determination of plasma trimetrexate levels using gas chromatography--mass spectrometry with selected-ion monitoringTrimetrexate is a potent inhibitor of dihydrofolate reductase and has demonstrated significant antitumor activity against murine and human cell lines both in vitro and against...
général - core.ac.uk - PDF: www.ncbi.nlm.nih.gov
The journal of infectious diseases • vol. 155, no.5. may 1987 potent effect of trimetrexate, a lipid-soluble antifolate, on toxoplasma gondiiTrimetrexate, a lipid-soluble antifolate, has considerably greater activity in inhibiting the dihydrofolate reductase of Toxoplasma gondii than do the conventional antifolates...
général - core.ac.uk - PDF: jid.oxfordjournals.org
Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome....
général - core.ac.uk - PDF: www.pubmedcentral.nih.gov


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