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tolafentrine

santé / chimie - iate.europa.eu

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In vitro differentiation of human monocytes to macrophages: change of pde profile and its relationship to suppression of tumour necrosis factor-α release by pde inhibitors... Combined use of PDE3 plus PDE4 inhibitors resulted in an additive effect and fully abrogated LPS-induced TNF release as did the mixed PDE3/4 inhibitor tolafentrine....

général - core.ac.uk - PDF: www.pubmedcentral.nih.gov

Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions.... The effect of non-selective (3-isobutyl-1-methylxanthine, IBMX; theophylline) and type IV- or type III/IV-selective (rolipram, RP 73401; zardaverine, tolafentrine) phosphodiesterase (PDE) inhibitors on human eosinophil functions was investigated....

PDF: www.pubmedcentral.nih.gov

Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migrationAbstract Background The aim of the study was to assess the chronic effects of combined phosphodiesterase 3/4 inhibitor tolafentrine, administered by inhalation, during monocrotaline-induced pulmonary arterial hypertension (PAH) in rats....

PDF: doaj.org

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