Integrated epigenetics of human breast cancer: synoptic investigation of targeted genes, micrornas and proteins upon demethylation treatment... Beside the activation of several epigenetically suppressed TSGs, we also showed significant dysregulation of some important oncogenes, oncomiRs and oncosuppressors miRNAs as well as drug tolerance genes/miRNAs/proteins.In...
Plasmodium falciparum in vitro continuous culture conditions: a comparison of parasite susceptibility and tolerance to anti-malarial drugs throughout the asexual intra-erythrocytic life cycle... Keywords: Malaria, Plasmodium falciparum, Drug tolerance, Intra-erythrocytic, Artemisinin, Lumefantrine, In vitro culture, Transcriptional variatio
Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy... The results of anti-cancer drug evaluation suggested a higher drug tolerance within the 3D tumor model compared to conventional 2D-cultured cells....
Response of emt6 multicellular tumour spheroids to hyperthermia and cytotoxic drugs... Using this model system, we have demonstrated enhanced BLM cytotoxicity at 43°C and also heat-induced drug tolerance to BLM at 43°C....
