In preferred embodiments, treaatment comprises the administration of thymosin α1 or antibodies to thymosin α1 or thymosin β4.
Inflammation or damage associated with myocardial events is treated or prevented by administration of an angiogenesis-inducing, anti-inflammatory peptide such as Thymosin β4, an isoform of Thymosin β4 or oxidized Thymosin β4.
Skin degradation associated with skin aging is inhibited or reversed by administration of an actin-sequestering peptide such as Thymosin β4, an isoform of Thymosin β4 or oxidized Thymosin β4.
The long lasting thymosin derivative is a thymosin derivative linked to polyethylene glycol (PEG) via covalent bond, as defined in the specification.
Neural precursor cells can be encouraged to form mature neural cells twice as quickly in the absence, or reduced expression of, thymosin β4.
A method for the solid phase peptide synthesis of thymosin alpha-1 is disclosed.
TB-500 is a short peptide segment or fragment of the naturally-occurring thymosin beta-4 hormone (TB-4.)
The invention also relates to pharmaceutical compositions comprising a lymphoid thymosin-β4 polypeptide or a functional lymphoid thymosin-β4 polypeptide variant, or salt thereof, and a pharmaceutically acceptable carrier.
In some embodiments, the actin-binding peptides comprise fragments of thymosin β4.
The present invention also provides pharmaceutical formulations comprising oxidised thymosin β4 together with a suitable excipient.
These methods include administering a composition comprising thymosin alpha 1 to a subject.
Another part is that thymosin beta-4 is potently anti-inflammatory.
TB-500 closely matches a short section of thymosin beta-4.
Thymosin-α1 is used as an adjuvant in combination with carmustine (BCNU) as an effective treatment for malignant glioblastoma.
This gamma-interferon (Ingaron) and tumor necrosis factor - thymosin alpha 1 (Refnot).
The invention concerns the use of thymosin alpha 1 for the preparation of a medicament for the prevention and treatment of allergies
The present invention relates to the use of truncated oxidized thymosin β4 in therapy, such as in the treatment of diseases or conditions associated with inflammation.
For healing injuries TB-500 may be just as effective as thymosin beta-4.
TB-500 is a synthetic peptide related to the hormone thymosin beta-4.
Belongs to the family of beta-thymosin (class of actin-binding proteins).
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