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tanespimycine

tanespimycin

général - eur-lex.europa.eu

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Combined delivery of paclitaxel and tanespimycin via micellar nanocarriers: pharmacokinetics, efficacy and metabolomic analysis.BACKGROUND: Despite the promising anticancer efficacy observed in preclinical studies, paclitaxel and tanespimycin (17-AAG) combination therapy has yielded meager responses in a phase I clinical trial....

général - core.ac.uk - PDF: doaj.org

Folate receptor-targeted hybrid lipid-core nanocapsules for sequential delivery of doxorubicin and tanespimycin... Co-administration of DOX with tanespimycin (TNP), an Hsp90 inhibitor, can sensitize the cancer cells to the cytotoxic effects of DOX....

PDF: repository.hanyang.ac.kr

Using the drug-protein interactome to identify anti-ageing compounds for humans... Finally, combining all the data, we calculated a ranked list of drugs that identified tanespimycin, an inhibitor of HSP-90, as the top-ranked novel anti-ageing candidate....

PDF: discovery.ucl.ac.uk

Rapid communication tipifarnib and tanespimycin show synergic proapoptotic activity... We decided to study LY294002, which inhibits PI-3 kinase, and tanespimycin (17AAG), which inhibits Hsp90—a chaperone for a number of proteins, including Akt kinase....

PDF: citeseerx.ist.psu.edu

Cost-effective, commercial scale production of tanespimycin... Hsp90 inhibitors have been receiving extensive research attention, with geldanamycin, tanespimycin, and their derivatives at the forefront....

PDF: repository.upenn.edu

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