L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats... In conclusion, l-arginine supplementation corrects local cardiac noradrenergic hyperactivity in the SHR, probably via increased pre-synaptic substrate availability of NOS–sGC–cGMP pathway and reduced tyrosine hydroxylase levels
Hyperexcitability of the local cortical circuit in mouse models of tuberous sclerosis complex... To decipher the synaptic substrate of hyperexcitability, we examined pan-neuronal Tsc1 knockout mouse and found a reduction in surface expression of a GABA receptor (GABAR) subunit but not AMPA...
Distinct eligibility traces for ltp and ltd in cortical synapses ... Notably, the temporal properties of these transient traces allow stable learning in a recurrent neural network that accurately predicts the timing of the reward, further validating the induction and transformation of eligibility traces for LTP and LTD as a plausible synaptic substrate for reward-based learning
Par-1 kinase phosphorylates dlg and regulates its postsynaptic targeting at the drosophila neuromuscular junction ... The ability of a nonphosphorylatable Dlg to largely rescue PAR-1-induced synaptic defects supports the idea that Dlg is a major synaptic substrate of PAR-1....
