The present invention pertains to polynucleotides derived from staphylococcal genes encoding resistance to streptogramin A or to streptogramin B and chemically related compounds.
Said derivatives are particular useful as antimicrobial agents, optionally combined with at least on group A streptogramin derivative.
Said derivatives are particularly useful as antimicrobial agents, optionally associated with at least a group A streptogramin derivative.
Said derivatives are particularly suitable for use as antimicrobial agents, optionally coupled with at least one group A streptogramin derivative.
A gene encoding an acetyltransferase inactivating streptogramin A was isolated from an Enterococcus faecium strain and sequenced.
Resistance to clindamycin usually occurs via macrolide-lincosamide-streptogramin B (MLSB) type of resistance, which may be constitutive or inducible.
The methylated nucleotide is located in a domain V and is thought to interact with the lincosamides and streptogramin B, in addition to macrolides, resulting in a phenotype known as MLSB resistance.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
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