Effect of the deletion of sco6673-like on the spiramycin and congocidine production.(A) Spiramycin and congocidine production was assessed directly by HPLC from supernatant samples collected from the culture of S....
Physicochemical properties and in vitro dissolution of spiramycin microparticles using the homogenate-antisolvent precipitation processDue to its low bioavailability and slow dissolution rate, the micronized spiramycin powder was thus prepared by the homogenate-antisolvent precipitation (HAP) process....
Selection of streptomyces ambofaciens mutants that produce large quantities of spiramycin and determination of optimal conditions for spiramycin production.The aim of this work was to develop a strategy to isolate a morphologically stable mutant of Streptomyces ambofaciens ATCC 15154 which produced high titers of spiramycin....
Spiramycin uptake by alveolar macrophagesThe in-vitro and in-vivo uptake of spiramycin by human and animal alveolar macrophages was studied....
