Curative and preventive anticryptosporidium activities of sinefungin in an immunosuppressed adult rat model.An immunosuppressed rat model was used to investigate the anti-Cryptosporidium parvum activity of sinefungin....
Regulation of sinefungin biosynthesis by the wild-type strain and mutants of streptomyces incarnatus.Sinefungin, an antifungal and antiparasitic antibiotic, is produced efficiently from ammonium citrate by prototrophic strains of Streptomyces incarnatus....
Mmei/dna/sinefungin ternary complex.... The flipped-out adenine (orange) and the bound Sinefungin (red) are labeled....
Sinefungin resistance of saccharomyces cerevisiae arising from sam3 mutations that inactivate the adomet transporter or from increased expression of adomet synthase plus mrna cap guanine-n7 methyltransferaseThe S-adenosylmethionine (AdoMet) analog sinefungin is a natural product antibiotic that inhibits nucleic acid methyltransferases and arrests the growth of unicellular eukarya and eukaryal viruses....
