The mutational spectrum of disease-causing alleles, including exonic copy number variations (CNVs), is complex.

(French : silenceur) DNA region located near a gene that has the capacity to reduce its transcription.

But if it be a part of a sign of which another part is ‘some man sings,’ the sign ‘some man is mortal’ becomes an interpretant of it.

The invention further relates to human Beclin 1 mutated at Ser234, Ser295, Tyr229, Tyr233 or Try352 with a phospho-silencing residue and uses thereof.

Plants are transformed with a silencing construct homologous to a gene of a plant pest that is essential for the survival, development, or pathogenicity of the pest.

Ten patients have been using the EMA2 and ten patients the Silencer device on a nightly basis (reportedly).

The invention relates to peptides derived from neural-restrictive silencer factor which modulate expression of CD59 and thus affect antibody-mediated complement cytotoxicity in tumours.

The amplifier sequence includes sequence domains (I) and (II), and the silencer sequence includes sequence domain (III). The use of said sequences in genetic engineering is also described.

In addition, the invention provides a variety of methods for using the vectors including for achieving gene silencing in eukaryotic cells and transgenic animals, and method's of treating disease.

This includes an ASO which silences intronic splicing in intron 7 (intron 7 intronic splicing silencer N1 (ISS-N1) so as to increase exon 7 inclusion.

With the Silencer, RDI decreased from 30±20/h to 13±13/h and minimal oxygen saturation increased from 81±12 to 88±4 percent.