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selfotel

santé / chimie - iate.europa.eu
Characterization of two novel n-methyl-d-aspartate antagonists: eaa-090 (2-[8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and eab-318 (r--amino-5-chloro-1-(phosphonomethyl)-1h-benzimidazole- 2-propanoic acid hydrochloride)...6-diazabicyclo[5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and EAB-318 (R--amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic acid hydrochloride), were compared with CGS-19755 (Selfotel) in ligand binding, elec-trophysiology, and neuroprotection assays....
général - core.ac.uk - PDF: jpet.aspetjournals.org
Structural analoguesof selfotelA small library ofphosphonopiperidylcarboxylic acids, analoguesof NMDA antagonist selfotel (CGS 19755), was synthesized....


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