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sémapimod

semapimod

général - eur-lex.europa.eu

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Pre-ercp infusion of semapimod, a mitogen-activated protein kinases inhibitor, lowers post-ercp hyperamylasemia but not pancreatitis incidence... Semapimod is a synthetic guanylhydrazone that inhibits the mitogen-activated protein kinase (MAPK) pathway, macrophage activation, and the production of several inflammatory cytokines....

général - core.ac.uk - PDF: www.loc.gov

Semapimod sensitizes glioblastoma tumors to ionizing radiation by targeting microglia.... We found that semapimod, a drug that selectively interferes with the function of macrophages and microglia, potently inhibits microglia-stimulated GL261 invasion, without affecting serum-stimulated...

PDF: doaj.org

Specific inhibition of c-raf activity by semapimod induces clinical remission in severe crohn's disease... In an earlier study, we reported clinical efficacy of a 2-wk treatment with semapimod (CNI-1493) in 12 patients with therapy resistant CD....

PDF: www.loc.gov

Semapimod removes microglia-induced radioprotection on gl261 in vitro.GL261 cells were cultured in the presence or absence of microglia and in the presence or absence of 200 nM of semapimod, followed by a colony formation assay....

PDF: figshare.com

Semapimod inhibits microglia-stimulated glioblastoma invasion in vitro.(A) Semapimod inhibits microglia-stimulated glioblastoma cell invasion....

PDF: figshare.com

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