Printed in u.s.a. copyright © 2001 by the endocrine society defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase*... Studies in vitro have indicated that NO has biphasic effects on both osteoclast (5, 11, 12) and osteoblast activity (2, 6, 13), whereas studies in vivo have suggested a possible role for constitutive NO production in regulating bone mass and bone turnover (14–19)....
The effect of three years of tnf alpha blocking therapy on markers of bone turnover and their predictive value for treatment discontinuation in patients with ankylosing spondylitis: a prospective longitudinal observational cohort studyIntroduction: The aim of this study was to investigate the effect of three years of tumor necrosis factor-alpha (TNF-alpha) blocking therapy on bone turnover as well as to analyze the predictive value of early changes in bone turnover markers (BTM) for treatment discontinuation in patients with ankylosing spondylitis ...
Human stem cell osteoblastogenesis mediated by novel glycogen synthase kinase 3 inhibitors induces bone formation and a unique bone turnover biomarker profile in rats ... Bone anabolism/resorption was determined using clinically relevant serum biomarkers as indicators of bone turnover and bone formation assessed in femurs by histopathology and pQCT/μCT imaging.GSK-3...
