Even between-lap pacing despite high within-lap variation during mountain biking...research on pacing strategies during competitive events, this study examined changes in dynamic high resolution performance parameters to analyse pacing profiles during a multiple-lap mountain bike race over variable terrain....
C/ebpβ-lap*/lap expression is mediated by rsk/eif4b-dependent signalling and boosted by increased protein stability in models of monocytic differentiation... During later stages of (pre)monocytic differentiation there is a considerable increase in the large C/EBPβ isoforms LAP*/LAP which inhibit proliferation thus supporting terminal differentiation....
Expression of lap*/lap is regulated by mek/rsk-dependent signalling pathways.(A) THP-1 monocytic cells were coincubated with the mTOR inhibitor (mTOR-I) rapamycin (100 nM) and/or 100 nM PMA for 24 h, and the levels of LAP*/LAP were determined (n = 3)....
Dramatic increase in c/ebpβ-lap*/lap proteins and lap/lip ratio in different models of monocytic differentiation.(A) THP-1 monocytic cells were incubated with 100 nM PMA up to 48 h, and the levels of the larger C/EBPβ isoforms (LAP*/LAP) and the small isoform LIP were monitored by Western blot analysis using whole cell extracts (loading control: actin; n = 6)....
