The apparent volume of distribution of quinagolide after single oral administration of radiolabelled compound was calculated to be approx.

In urine, the main metabolites are the glucuronide and sulphate conjugates of quinagolide and the N-desethyl, N,N-didesethyl analogues.

concomitant therapy with dopaminergic agonists (cabergoline, quinagolide) when used not for the treatment of Parkinson's disease (see "Interaction").

Future studies should examine the effectiveness and safety of various dopamine agonists including bromocriptine, cabergoline and quinagolide.

If lactation should continue during treatment, breast-feeding cannot be recommended because it is not known whether quinagolide passes into human breast milk.

Studies performed with 3H-labelled quinagolide revealed that more than 95% of the drug is excreted as metabolites.

With dopaminergic agonists (cabergoline, quinagolide) when used not for the treatment of Parkinson's disease - the mutual antagonism of the effects of dopaminergic receptor agonists and neuroleptics.

The LD50 of quinagolide was determined for several species after single oral administration: mice 357 to > 500 mg/kg; rats > 500 mg/kg; rabbits > 150 mg/kg

If lactation should continue during treatment, breast-feeding cannot be recommended because it is not known whether quinagolide passes into human breast milk.

The LD50 of quinagolide was determined for several species after single oral administration: mice 357 to > 500 mg/kg; rats > 500 mg/kg; rabbits > 150 mg/kg

Quinagolide, the active ingredient of NORPROLAC, is a selective dopamine D2-receptor agonist not belonging to the chemical classes of ergot or ergoline compounds.

Long-term studies with high doses of quinagolide revealed Leydig cell tumours in rats and mesenchymal uterine tumours in mice.

These changes were reversible and reflect the pharmacodynamic effect of quinagolide: suppression of prolactin secretion inhibits luteolysis in rats and thus influences the normal sexual cycle.

Plasma concentration values obtained by a non-selective radio- immunoassay (RIA), measuring quinagolide together with some of its metabolites, were close to the limit of quantification and gave no reliable information.

Prolactin secretion can be returned to normal levels through drugs or herbal supplements that stimulate dopamine, including bromocriptine, cabergoline, quinagolide, and the herb roseroot.