Surprinsingly, it has been discovered that the core protein antigen of Toscana virus can induce a protective humoral response.
In one embodiment, an immunoassay for measuring the amount of HCV core protein in an in vitro HCV replicating system is used.
Preferably the signal peptide peptidase targeting sequence is derivable from hepatitis C virus (HCV) core protein or a derivative, variant or homologue thereof.
The invention relates to compositions comprising Toscana virus nucleoprotein.
Up until now, the ATM protein has always been considered as cell nucleus protein and no study had probed its presence in the cytoplasm.
More specifically the invention is directed to a method for the attachment of an amino acid, amino acid derivative, peptide or polypeptide, nucleophile to a protein core obtained from a protein of the core and a leaving group.
The research focuses on an important protein of the cell nucleus (eIF4E) found in overabundance in several cancers, notably certain types of leukemias.
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