Methods and compositions to reduce immunogenicity of proteins are disclosed.
A central feature of the invention are microorganisms which are avirulent as a result, in whole or in part, of a mutation in phoP, but which retain their immunogenicity.
The present invention provides methods for combining computational methods for modulating protein immunogenicity with computational methods for identifying sequences with desired structural and functional properties.
This vaccine is both immunogenic and protective in non-human primates.
The protein carrier is selected for its high immunogenic capability, especially with regards to T-cells.
The invention concerns a novel method for sensitising antigen-presenting cells, novel means for implementing the method, and novel membrane vesicles with immunogenic properties.
A gene encoding a superantigen, such as an M-like protein of group A streptococci, can be introduced into a tumor cell in order to make the tumor cell more immunogenic in the host.
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