Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase b1 (tbrpdeb1)... Herein, we report our continuing efforts to repurpose the human phosphodiesterase 4 (hPDE4) inhibitor piclamilast to target trypanosomal phosphodiesterase TbrPDEB1....
Effect of piclamilast and/or tadalafil on cigarette smoke-induced lung emphysema development assessed by in vivo lung functional parameters.Mice were exposed to cigarette smoke for 6 months and treated in parallel with Piclamilast (10 mg/kg body weight/day) and/or Tadalafil (10 mg/kg body weight/day)....
Effect of piclamilast and/or tadalafil on cigarette smoke-induced lung emphysema development assessed by structural parameters.Mice were exposed to cigarette smoke for 6 months and treated in parallel with Piclamilast (10 mg/kg body weight/day) and/or Tadalafil (10 mg/kg body weight/day)....
Systemic effects of smoke exposure and treatment with piclamilast and/or tadalafil in mice.Mice were exposed to cigarette smoke for 6 months and treated in parallel with Piclamilast (10 mg/kg body weight/day) and/or Tadalafil (10 mg/kg body weight/day)....
