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Dictionnaire français - anglais

phosphonoformate

foscarnet

santé - iate.europa.eu
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Inhibition of human herpesvirus 6 replication by 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (2hm-hbg) and other antiviral compounds.The in vitro susceptibilities of human herpesvirus 6 to foscarnet; the guanosine analogs acyclovir, ganciclovir, and two isomers of 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine; and the thymidine analogs 3'-azido-3'-deoxythymidine and...
santé - core.ac.uk - PDF: www.pubmedcentral.nih.gov
Cytomegalovirus colitis and oesophageal ulceration in the context of aids. clinical manifestations and a preliminary report of treatment with foscarnet (phosphonoformate... The patients were treated with a 14 day continuous infusion of Foscarnet 0-08 mg/kg/min (phosphonoformate, Astra Pharmaceuticals)....
 PDF: gut.bmj.com
Inhibition of human immunodeficiency virus in vitro by combinations of 3'-azido-3'-deoxythymidine and foscarnet.We describe a synergistic effect of combinations of foscarnet and 3'-azido-3'-deoxythymidine against human immunodeficiency virus type 1 multiplication in cell culture, an additive effect of foscarnet and 3'-azido-3'-deoxythymidine...
 PDF: www.pubmedcentral.nih.gov

trisodium phosphonoformate

santé - iate.europa.eu
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Foscarnet as treatment for cytomegalovirus retinitis following bone marrow transplantation.... Following allogeneic bone marrow transplantation, he developed cytomegalovirus retinitis, which was treated successfully with trisodium phosphonoformate (foscarnet)....
santé - core.ac.uk - PDF: www.pubmedcentral.nih.gov
phosphonoformate

phosphonoformate

santé - iate.europa.eu
Un procédé et une composition servent à traiter des infections virales par l'encapsulage dans des liposomes des composés anti-viraux phosphonoformate et phosphonoacétate.

A method and composition for treating viral infections by liposome-encapsulation of the anti-viral compounds phosphonoformate and phosponoacetate.

santé - wipo.int
L'invention porte sur des procédés de traitement d'infections dues au VIH chez un patient le nécessitant au moyen d'analogues lipidiques de composés à activité pharmaceutique contenant du phosphonoformate.

The invention provides methods for treating HIV infection in a subject in need thereof comprising lipid analogs of phosphonoformate-containing pharmaceutically active compounds.

santé - wipo.int
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Activity of (+)-cyclaradine (sch 31172) against herpes simplex virus in vitro and in vivo.... (+)-Cyclaradine has in vitro activity nearly equivalent to that of phosphonoformate but is significantly less active than acycloguanosine (acyclovir; ACV), trifluorothymidine, or 9-(1,3-dihydroxy-2-propoxymethyl)guanine....
santé - core.ac.uk - PDF: www.pubmedcentral.nih.gov

Publications scientifiques

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Antiviral agents against equid alphaherpesviruses : current status and perspectives... Antiviral drugs,particularly nucleoside analogues and foscarnet, are successfully used for the treatment of human alphaherpesvirus infections....
recherche et propriété intellectuelle / santé / activité agricole - core.ac.uk -
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Synergism among biolf-62, phosphonoformate, and other antiherpetic compounds.9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine (BIOLF-62) is highly synergistic with either phosphonoformate or phosphonoacetate when used in combination against herpes simplex virus types 1 and 2 in vitro....
général - core.ac.uk - PDF: www.pubmedcentral.nih.gov
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Inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoformatePhosphonoformate was found to be an inhibitor of the deoxyribonucleic acid polymerase induced by the herpesvirus of turkeys....
général - core.ac.uk - PDF: www.pubmedcentral.nih.gov
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Reversible effects on cellular metabolism and proliferation by trisodium phosphonoformateThe antiviral compound trisodium phosphonoformate (PFA), which inhibits herpesvirus multiplication by 50% at a concentration of 10 μM, did not show any effects on macromolecular synthesis and cell proliferation...
général - core.ac.uk - PDF: www.pubmedcentral.nih.gov
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Topical treatment of recurrent genital herpes simplex virus infections with trisodium phosphonoformate (foscarnet): double blind, placebo controlled, multicentre study....double blind, placebo controlled trial was performed in nine sexually transmitted diseases (STD) clinics in the United Kingdom and the Netherlands to investigate the efficacy of trisodium phosphonoformate (foscarnet) cream in treating recurrent genital herpes simplex virus (HSV) infection....
général - core.ac.uk - PDF: www.pubmedcentral.nih.gov

Synonymes et termes associés français

trisodium phosphonoformate

•

Foscarnet

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foscavir

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phosphonoformiate

Traductions en contexte français - anglais

On a découvert que ce dernier est au moins aussi efficace que le phosphonoformate pour inhiber la réplication virale de CMV, tandis que sa biodisponibilité est sensiblement améliorée par rapport au phosphonoformate.

TPFA is demonstrated to be at least as effective as PFA in inhibiting CMV viral replication, while having substantially improved bioavailability relative thereto.

santé - wipo.int
Nouveaux composés dérivés de phosphonoformate, processus de synthèse de ces composés et utilisation de ces composés comme agents antiviraux.

The present invention pertains to novel compounds which are derivatives of phosphonoformic acid, processes for their synthesis and their use as antiviral agents.

chimie - wipo.int
La présente invention concerne la préparation d'analogues de phosphonoformate contenant un, deux, trois atomes de soufre ou plus, et des exemples spécifiques de ces derniers.

Preparation of phosphonoformic acid analogues containing one, two, three, or more sulfur atoms are described, with specific examples.

chimie - wipo.int
Procédés et compositions servant à inhiber la réplication du cytomégalovirus (CMV) chez des mammifères, lesdits procédés consistant à leur administrer une quantité efficace de trisodium phosphonoformate.

Methods and compositions for use in inhibiting CMV replication in mammalian patients, wherein an effective amount of TPFA is administered to a patient in need of such treatment.

santé - wipo.int


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