The present invention features therapeutic bacteriophage deficient in the lysin protein ('Lys minus' phage).
The present invention relates to methods of obtaining bacteriophage ('phage'), such as lambda phage, for industrial uses, such as for use in commercial vaccine production.
These viruses are called bacteriophages or simply phages.
It is not the best candidate for use in bacteriophage therapy because it is a prophage – also known as a temperate phage or lysogenic phage.
The invention provides a transformation system based on bacteriophage Mx9, a temperate phage that infects Myxococcus xanthus.
In a preferred embodiment, said phage is a T7 phage.
This invention encompasses for an isolated Bacillus phage AP50 that has one or more nucleotide substitutions in the phage genome, whereby the one or more nucleotide substitutions increase lytic activity of the phage.
The present disclosure provides new and improved phage display methodologies.
Uses of the modified phage and kits containing the phage are also provided.
Infection of a bacterium by a phage may be indicative of phage binding to the target molecule.
Infection of a bacterium by a phage may be indicative of phage binding to the target molecule and/or target microorganism.
Transductor phage (French : phage transducteur) Phage that has the property to transfer part of a genome from the host cell to another.
The invention provides a complex inducible promoter system derivable from a phage of a lactic acid bacterium, especially one having the DNA sequence of SEQ.
DNA encoding phage resistance protein which aborts infection by the phage, designated as AbiE.
The methods and kits of the invention may be employed to type strains of L. lactis into phage-sensitivity groups, and sub-type the phage-sensitivity groups according to phage sensitivity.
Binding elements of the invention comprise phage which in most embodiments express a peptide of interest on the phage surface.
Phage-nanoparticle assemblies of the invention comprise a plurality of nanoparticles complexed with one or more phage particles to form a phage-nanoparticle assembly.
The invention describes the display of exogenous polypeptides on filamentous phage using a fusion between the exogenous polypeptide and phage pVII or pIX proteins.
The phage thus constructed is usable in gene therapy.
Typically, the phage are labeled with a detectable signal.
Also disclosed are methods of making and using modified phage comprising post-translationally modified proteins located on the surface of the phage.
Rather than detecting the binding of the phage using antibody-based technology, the present invention relates to detecting the nucleic acid associated with the phage.
The phage DNA in this repressed state is called a prophage because it is not a phage but it has the potential to produce phage.
Transductor phage (French : phage transducteur) Phage that has the property to transfer part of a genome from the host cell to another.
The phage, carrying the modified gene is introduced into a host.
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