Antibiotic induced electrophoretic mobility shifts of dna restriction fragments.Several antibiotics, netropsin, distamycin A, actinomycin D, Hoechst 33258 and olivomycin, which demonstrate base specificity in their DNA binding properties have been found to alter the electrophoretic mobility of DNA restriction fragments in native polyacrylamide...
Modelling basic features of specificity in dna-aureolic acid-derived antibiotic interactions AbstractThe nonintercalative groove binding of a simplified model of olivomycin, to sequences d(CGCGCGC)2, d(TATATAT)2, and d(CICICIC)2, is investigated....
Divalent cations are dispensable for binding to dna of a novel positively charged olivomycin a derivative>The current model of binding of the antitumor antibiotic olivomycin A (1) to GC-rich DNA regions presumes that coordination of the magnesium divalent cation with drug dimers is necessary for binding of 1 into the minor groove of the...
Divalent cations are dispensable for binding to dna of a novel positively charged olivomycin a derivative.The current model of binding of the antitumor antibiotic olivomycin A (1) to GC-rich DNA regions presumes that coordination of the magnesium divalent cation with drug dimers is necessary for binding of 1 into the minor groove of the...
