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The tumor targeted superantigen abr-217620 selectively engages trbv7-9 and exploits tcr-pmhc affinity mimicry in mediating t cell cytotoxicity.... The conceptual objective for developing the tumor targeted superantigen (TTS) ABR-217620 (naptumomab estafenatox, 5T4Fab-SEA/E-120), now in phase 3 studies for advanced renal cell cancer, was to selectively coat tumor cells with cytotoxic T lymphocytes (CTL) target...

général - core.ac.uk - PDF: doaj.org

Antibody-based therapeutics to watch in 2011... In alphanumeric order, the 2011 therapeutic antibodies to watch list comprises AIN-457, bapineuzumab, brentuximab vedotin, briakinumab, dalotuzumab, epratuzumab, farletuzumab, girentuximab (WX-G250), naptumomab estafenatox, necitumumab, obinutuzumab, otelixizumab, pagibaximab, pertuzumab, ramucirumab, REGN88, reslizumab, solanezumab, T1h, teplizumab, trastuzumab emtansine,...

PDF: www.pubmedcentral.nih.gov

Dose finding with escalation with overdose control (ewoc) in cancer clinical trials... In particular, we show in therecently completed ABR-217620 (naptumomab estafenatox) trial that omitting animportant predictor of toxicity when dose assignments to cancer patients aredetermined results in a high percent of patients experiencing...

PDF: www.imstat.org)

A randomized phase ii/iii study of naptumomab estafenatox + ifnα versus ifnα in renal cell carcinoma: final analysis with baseline biomarker subgroup and trend analysisPurpose: To prospectively determine the efficacy of naptumomab estafenatox (Nap) þ IFNa versus IFN in metastatic renal cell carcinoma (RCC).Experimental...

PDF: repo.dma.dp.ua

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Dictionnaire français - anglais

naptumomab estafénatox

naptumomab estafenatox