Some pharmacological properties of the circular and longitudinal muscle strips from the guinea-pig isolated ileum... Incubation of the preparations with the anticholinesterase, mipafox (NN-diisopropylphosphodiamidic fluoride), sensitized both preparations to the action of acetylcholine; potentiation of the contraction of the longitudinal muscle was 16-times;...
Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (nt2) caused by exposure to organophosphorus compounds paraoxon and mipafox... We studied the initial stages of retinoic acid acid-triggered differentiation of pluripotent cells towards neural progenitors derived from human embryonal carcinoma stem cells to determine if neuropathic OP, mipafox, and non-neuropathic OP, paraoxon, are able to alter differentiation of neural precursor cells in vitro....
Kinetics of substrate hydrolysis and inhibition by mipafox of paraoxon-preinhibited hen brain esterase activity.For the purpose of assessing the neurotoxic potential of organophosphorus compounds, it has been determined that paraoxon-preinhibited hen brain has both neurotoxicant (mipafox)-sensitive (neurotoxic esterase; NTE) and -insensitive esterase components....
Protective role of verapamil against organophosphorus ester induced delayed neurotoxicity (short communication)The protective efficacy of a well-known calcium channel blocker, Verapamil, against Mipafox, a prototype of nerve gas, has been investigated....
