Hypnotic effects of an antihistamine— methapyrilene hydrochloride*...e.g., methapyrilene hydrochloride, are adver-tised extensively to the public and sold in large quantities for their hypnotic effect since, unlike other hypnotics such as the barbiturates,...
Sequential morphologic changes during methapyrilene-induced hepatocellular carcinogenesis in rats 1,2,3,4ABSTRACT- The pathogenesis of hepatocellular tumors induced in F344 rats by the antihistaminic methapyrilene was investigated by light and electron microscopy in a serial sacrifice study....
Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue... METHODS: Male rats were given the hepatotoxicant methapyrilene at two dose levels, with livers and kidneys removed 24 hr after one, three, and seven doses for gene expression analysis....
Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the ratAdministration of high doses of the histamine antagonist methapyrilene to rats causes periportal liver necrosis....
