Induction of ermsv by 16-membered-ring macrolide antibiotics.... Four types of responses which were correlated with the macrolide ring size were seen, as follows: group 1, both ermSV and ermC were induced by the 14-membered-ring macrolides erythromycin, lankamycin, and matromycin, as well as by the lincosamide celesticetin; group 2, neither ermSV nor ermC was induced by the 12-membered-ring macrolide methymycin or by the lincosamide lincomycin or the streptogramin type B antibiotic ostreogrycin B; group 3, ermSV was selectively induced over ermC by the 16-membered-ring macrolides carbomycin, chalcomycin, cirramycin, kitasamycin, maridomycin, and tylosin; and group 4, ermC was selectively induced over ermSV by the 14-membered-ring macrolide megalomicin....
Polymorphism and structural maturation of bunyamwera virus in golgi and post-golgi compartments... Megalomicin, a drug that disrupts the trans side of the Golgi complex, reversibly blocks transformation, showing that a functional trans-Golgi is needed for maturation....
The ermc leader peptide: amino acid alterations leading to differential efficiency of induction by macrolide-lincosamide-streptogramin b antibiotics.The inducibility of ermC by erythromycin, megalomicin, and celesticetin was tested with both wild-type ermC and several regulatory mutants altered in the 19-amino-acid-residue leader peptide, MGIFSIFVISTVHYQP NKK....
Megalomicin inhibits hiv-1 replication and interferes with gp160 processing AbstractThe inhibitory effects on HIV replication of megalomicin (MGM), an inhibitor of intra-Golgi vesicle transport, have been studied....
