The activated cytotoxic T cell then kills the infected cell.
In particular, the invention provides a method and formulation for induction of cytotoxic T cell responses against a polypeptide antigen of choice.
The invention provides the nucleotide sequence and amino acid sequence of the CDR3 domain of the T cell receptor (TCR) gene of a WT1 specific cytotoxic T cell (CTL) against WT1 protein.
An EP1 agonist has an activity to activate a cytotoxic T cell and/or an activity to activate a natural killer cell, and therefore can exhibit an immunopotentiating activity.
The immunological synapse formed between a cytotoxic T cell and an infected or a transformed target cell is a physically active structure capable of exerting mechanical force.
A cytotoxic t lymphocyte is a type of white blood cell and a type of lymphocyte.
A cytotoxic T lymphocyte is a type of white blood cell and a type of lymphocyte.
Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro.
The cytotoxic T lymphocyte and/or NKT cells can be induced by the intratumoral introduction of immature dendritic cells to the patient.
The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope.
The activated killer T cell then kills the infected cell.
The cytotoxic T-cell specific to the peptide has an ability of causing damage on a cancer cell capable of expressing GPNMB.
Variants of cytotoxic T-lymphocyte antigen 4 (CTLA-4) with high affinity, potency and stability.
The method includes, for example, administering a cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) molecule and a Type 1 diabetes autoantigen.
Also, the present invention provides an ebola virus antigen peptide that can induce cytolytic T lymphocytes restricted to HLA-A*0201 or HLA-A*2402.
In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family.
Each of the peptides has a function of effectively inducing an adenovirus-specific cytotoxic T-cell (CTL) and is therefore useful as a vaccine for active immunization.
The peptide fragment is capable of binding in an HLA-A2 binding cleft and is capable of stimulating proliferation of at least one tumor-specific cytotoxic T-lymphocyte.
The peptide-bonded liposome and the peptide are useful as an ebola virus vaccine or a cytolytic T lymphocyte activation agent.
Preferably, the composition comprises a water-in-oil formulation including at least one antigen to which the individual will mount an anamnestic response and at least one cytotoxic T-cell epitope.
The antiviral protection against drug-resistant virus shown by compositions of the present invention and mediated by human HLA-restricted CTL has not been previously achieved.
A method of treating, preventing, or delaying the progression of Type 1 diabetes mellitus autoimmunity by administering an effective amount of a cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) molecule is provided herewith.
Disclosed are: polypeptides for TCR α-chain and β-chain which are restricted to HLA-A*0201 for Aur-A and are derived from a CTL; and nucleic acids encoding the polypeptides.
The peptide can be presented by an antigen-presenting cell, and has an ability of activating and proliferating a cytotoxic T-cell specific to the peptide (i.e., an immune response-inducing ability).
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Traduction Translation Traducción Übersetzung Tradução Traduzione Traducere Vertaling Tłumaczenie Mετάφραση Oversættelse Översättning Käännös Aistriúchán Traduzzjoni Prevajanje Vertimas Tõlge Preklad Fordítás Tulkojumi Превод Překlad Prijevod 翻訳 번역 翻译 Перевод