In embodiments of the present invention, the cell surface receptor ligand is not a low-density lipoprotein receptor ligand and the cell surface receptor ligand is covalently bonded to the apoprotein.
Disclosed are a novel method for regulating the expression of a low-density lipoprotein receptor (LDLR) and a novel enhancer of the expression of a LDLR, both of which can increase the expression level of a LDLR.
A mutant low-density lipoprotein receptor related protein-1 binds to Alzheimer amyloid-beta (Aβ) peptide with greater affinity compared to its wild- type homolog.
It has been discovered that the low density lipoprotein receptor (LDLR) degrades the lipoprotein apoB.
The fusion protein is preferably retained in the endoplasmic reticulum of the cell, where the LDLR can degrade apoB.
The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member.
Human LDLR genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
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