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leucoencéphalite multifocale évolutive

progressive multifocal leuco-encephalopathy

santé - iate.europa.eu

PML

santé - iate.europa.eu

Publications scientifiques

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Hsv-1 genome subnuclear positioning and associations with host-cell pml-nbs and centromeres regulate lat locus transcription during latency in neurons... Latent HSV-1 genomes display two major patterns, called “Single” and “Multiple”, which associate with centromeres, and with promyelocytic leukemia nuclear bodies (PML-NBs) as viral DNA-containing PML-NBs (DCP-NBs)....

santé / industries nucléaire et électrique / activité agricole - core.ac.uk - PDF: figshare.com

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Flow cytometric immunobead assay for fast and easy detection of pml-rara fusion proteins for the diagnosis of acute promyelocytic leukemia...al.The PML-RARA fusion protein is found in approximately 97% of patients with acute promyelocytic leukemia (APL)....

santé - core.ac.uk - PDF: core.ac.uk

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Proteins associated with the promyelocytic leukemia gene product (pml)-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradationSeveral recent findings have indicated that the promyelocytic leukemia gene product (PML) oncogenic domains (PODs) are involved in proteasome-mediated degradation of ubiquitinated proteins....

produit agricole transformé / santé - core.ac.uk - PDF: www.pubmedcentral.nih.gov

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Regulation of promyelocytic leukemia protein expression...necessary.IFNer.inducedexpressionof PML at mRNA andproteinlevel and zubsequentincreaseof PML NBs are suppressedby all tested HDACIs independentlyon cellular origin....

santé / activité agricole - core.ac.uk - PDF: www.nusl.cz

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Clinical observations, interventions, and therapeutic trials molecular analysis and clinical outcome of adult apl patients with the type v pml-rara isoform: results from intergroup protocol 0129The type V (for variable) promyelocytic leukemia retinoic acid receptor (PML-RAR)a transcript, found in approximately 8 % of adult patients with acute promyelo-cytic leukemia (APL), is defined molecu-larly by truncation of PML exon 6 and frequent insertion...

santé - core.ac.uk - PDF: www.bloodjournal.org