Skin sensitisation: (allergic contact dermatitis) is an immunologically mediated cutaneous reaction to a substance.
if the hazard pictogram GHS08 applies for respiratory sensitisation, the hazard pictogram GHS07 shall not appear for skin sensitisation or for skin and eye irritation.
Lymphocyte proliferation should be measured during the induction phase of skin sensitisation
Evidence of skin sensitisation in humans normally is assessed by a diagnostic patch test.
For respiratory sensitisation, the pattern of induction followed by elicitation phases is shared in common with skin sensitisation.
Applying non-animal strategies for assessing skin sensitization
(b) in respect of which animal data acquired from scientifically validated methods for the evaluation of skin sensitization support the probability of a high skin sensitization rate in humans
Three new Standards based on the dermal sensitization QRA (Quantitative Risk Assessment).
It studies the induction phase of skin sensitisation and provides quantitative data suitable for dose response assessment.
(b) in respect of which animal data acquired from scientifically validated methods for the evaluation of skin sensitization support the probability of a low to moderate skin sensitization rate in humans
Three new Standards based on the dermal sensitization QRA (Quantitative Risk Assessment).
One revised Standard, based on the dermal sensitization QRA, with a corrected maximum pragmatic use level.
It can be a reaction known as respiratory sensitization, or it could be the more common type, which is dermal sensitization.
This pictogram refers to health hazards such as skin irritation or sensitisation, and eye irritation.
Similar to the LLNA, the LLNA: DA studies the induction phase of skin sensitisation and provides quantitative data suitable for dose-response assessment.
Therefore, classification will normally be based on human evidence which will be similar to that for skin sensitisation.
Therefore, classification will normally be based on human evidence which will be similar to that for skin sensitisation.
Therefore, classification will normally be based on human evidence, similar to that for skin sensitization.
Therefore, classification will normally be based on human evidence, similar to that for skin sensitization.
One revised Standard, based on the dermal sensitization QRA, with a corrected maximum pragmatic use level.
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