1 targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal rna cleavage... When selective kinase inhibitors were used to identify potential upstream signals, RNA activated protein kinase (PKR), hematopoietic cell kinase (Hck) and p38 were found to be required for rRNA cleavage, whereas JNK and ERK were not....
Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal rna cleavage. toxicological sciences: an official journal of the society of toxicology. 2012; 127(2):382–90. epub 2012/04/12. doi: 10.1093/toxsci/kfs134 pmid... When selective kinase inhibitors were used to identify potential upstream signals, RNA-activated protein kinase (PKR), hematopoietic cell kinase (Hck), and p38 were found to be required for rRNA cleavage, whereas c-Jun N-terminal kinase and extracellular signal-regulated kinase were not....
Novel virtual lead identification in the discovery of hematopoietic cell kinase (hck) inhibitors: application of 3d qsar and molecular dynamics simulationHigh level of hematopoietic cell kinase (Hck) is associated with drug resistance in chronic myeloid leukemia....
Suppression of hematopoietic cell kinase ameliorates the bone destruction associated with inflammation... The inhibitory effect on TNF-α-induced osteoclast differentiation of A-419259, a potent inhibitor of hematopoietic cell kinase (Hck), was examined....
