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Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human c-raf kinase supports an antisense mechanism of action in vivoTo determine the mechanism of action responsible for the in vivo antitumor activity of a phosphorothioate antisense inhibitor targeted against human C-raf kinase (ISIS 5132, also known as CGP69846A), a series of mismatched phosphorothioate analogs of ISIS 5132 or CGP69846A were synthesized...
santé - core.ac.uk - PDF: www.pubmedcentral.nih.gov

Publications scientifiques

Measurement of mirna by qpcr after antisense inhibitor transfection does not reliably measure the level of the cellular mirna.qPCR of miR-200a and miR-125b in MCF7 cells following transfection with antisense miR-200a (antisense inhibitor), or after its addition post lysis (doping), or both....
général - core.ac.uk - PDF: figshare.com
Activation of mir-29a in activated hepatic stellate cells modulates its profibrogenic phenotype through inhibition of histone deacetylases 4.... Primary HSCs from both mice were treated with a miR-29a mimic and antisense inhibitor in order to analyze changes in profibrogenic gene expression and HSC activation using real-time quantitative RT-PCR, immunofluorescence staining, western blotting,...
général - core.ac.uk - PDF: doaj.org
7sl srna5cd and 7sl srna8b do not function like mirnas.... (B) The luciferase reporter was co-transfected with the 2′-OMe antisense inhibitor (AS) against 7SL sRNA5cd or 7SL sRNA8b into HEK293T and HepG2.2.15...
général - core.ac.uk - PDF: figshare.com

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