The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag-pol.
The hepadnavirus polymerase gene product is produced by in vitro expression of a hepadnavirus pol gene.
The pol gene of the HIV genome in the particle is modifed to inactivate the pol reverse transcriptase and protease activity.
This pol gene can be on the first or second vectors or on a third vector.
HIV integrase is a DNA nucleotidyltransferase encoded by the pol gene.
In the expression cassette, the transcribed 5' hairpin structure of the Pol III gene is deleted.
polymerase (pol) codes for the enzymes reverse transcriptase, protease, and integrase
PNPase is produced by using Escherichia coli, etc. having a T7 RNA polymerase gene which has been transformed by an expression vector carrying a PNPase gene and a T7 promoter ligated together.
Lentiviruses are unique in that they contain open reading frames (ORFs) between the pol and env genes and in the 3' env region.
The retrovirus genome is typically made up of three genes: the group-specific antigen gene (gag), the polymerase gene (pol), and the envelope gene (env).
Pol δ, which is a three subunit enzyme, is encoded by the POLD1 gene, whereas Pol ε, a four subunit enzyme, is encoded by the POLE gene.
Pharmaceutical compositions which comprise HIV Pol DNA vaccines are disclosed, along with the production and use of these DNA vaccines.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
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