The present invention relates to a variant form of the receptor for the obese gene product.
The present invention relates to a variant form of the receptor for the obese gene product.
The invention relates to the Ob gene transcriptional promoter.
In particular, the Rhesus ob gene and gene product are disclosed.
Ob gene promoters are used in diagnosis and pharmaceutical development.
In particular, transfected adipocytes comprising Ob gene promoters operably linked to a reporter are used in high-throughput pharmaceutical screens.
The invention is useful for purifying the ob gene product, its fragments, and analogs.
Modulators of ob gene expression may be used to treat other diseases such as obesity, diabetes, hypertension, cardiovascular diseases and infertility.
The ob receptor has numerous isoforms resulting from alternative splicing; three novel isoforms, designated c', f, and g are disclosed.
The invention includes isolated DNA molecules that encode two different forms of the human ob gene product which regulate obesity in mammals, especially humans.
It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level of expression of an ob gene.
In particular, the invention relates to methods of detecting this receptor variant in cells and tissues of obese individuals.
In particular, the invention relates to methods of detecting this receptor variant in cells and tissues of obese individuals.
Novel monoclonal and polyclonal antibodies that selectively bind to various biologically active fragments and fragment analogs of the mammalian ob gene product are claimed.
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