Studies to validate the comet assay in measuring differential radiation-induced dna damage in cancer cells.... In this study two different theories were investigated to determine the reason for the differential measures of comet formation noted between bladder cancer cell lines....
Msh3-silencing leads to increased double strand breaks in hcecs.... From each culture three slides were prepared and from each slide 50 cells were analyzed for comet formation....
The large gtpase dynamin regulates actin comet formation and movement in living cells... Interestingly, comet formation and motility were normal in cells expressing wild-type Dyn2-GFP but altered markedly in Dyn2 mutant-expressing cells....
In vitro dna-damaging effects of intestinal and related tetrapyrroles in human cancer cells ... Eight tetrapyrroles (unconjugated bilirubin, bilirubin ditaurate, biliverdin, biliverdin-/bilirubin dimethyl ester, urobilin, stercobilin and protoporphyrin) were added to cultured Caco2 and HepG2 cells and their effects on comet formation (% tail DNA) were assessed....
