Significance of cobalamin inactivation in normal and malignant hematopoiesisThis thesis deals with several aspects of the effects of cobalamin inactivation bynitrous oxide on cellular folate metabolism and the consequences on normal and malignant hematopoiesis....
Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells... These results establish for the first time that MRP1 is the primary folate efflux route in CEM leukemia cells and that the loss of folate efflux activity is an efficient means of markedly augmenting cellular folate pools....
Antifolate resistance associated with loss of mrp1 expression and function in chinese hamster ovary cells with markedly impaired export of folate and cholateExport of folates from a Chinese hamster ovary PyrR100 cell line is markedly impaired, resulting in expansion of cellular folate pools and high-level antifolate resistance....
Cellular folate vitamer distribution during and after correction of vitamin b12 deficiency: a case for the methylfolate trap.... Other manifestations of the methylfolate trap include cellular folate loss because of shorter 5MTHF polyglutamate chains and global hypomethylation....
