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fendiline

fendiline

santé / chimie - iate.europa.eu
Cette invention concerne de nouveaux dérivés de fendiline, comprenant des composés de formule : dont les variables sont telles que définies dans la description.

Disclosed herein are novel derivatives of fendiline, including compounds of the formula: wherein the variables are defined herein.

chimie - wipo.int
Cette invention concerne la 3,3-diphényl-N-(1-phényléthyl)propan-1-amine (fendiline), à titre de nouveau ligand sélectif des récepteurs sigma-1, ayant des propriétés anti-apoptotiques (cytoprotectrices) et une activité anticancéreuse prototypique.

3,3-diphenyl-N-(l-phenylethyl) propan-l-amine (fendiline): as a new selective ligand of the sigma-1 receptors, with anti-apoptotic (cytopro- tective) properties and prototypical anticancer activity.

santé - wipo.int
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Novel cell-based in vitro screen to identify small-molecule inhibitors against intracellular replication of cryptococcus neoformans in macrophages ... Secondary screening and host cell cytotoxicity assays highlighted fendiline hydrochloride as a potential drug candidate for the development of future anticryptococcal therapies....
santé - core.ac.uk -

Publications scientifiques

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Fendiline inhibits l-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study.... Fendiline, a diphenylalkylamine type of antianginal drug, was examined for its effects on L-type calcium channels in guinea-pig ventricular myocytes by the whole-cell patch-clamp...
général - core.ac.uk - PDF: www.pubmedcentral.nih.gov
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Liquid chromatographic resolution of fendiline and its analogues on a chiral stationary phase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acidFendiline, an effective anti-anginal drug for the treatment of coronary heart diseases, and its sixteen analogues were resolved on a CSP based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic...
général - core.ac.uk - PDF: doaj.org
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Kinetic modulation of guinea-pig cardiac l-type calcium channels by fendiline and reversal of the effects of bay k 8644.... The modulation of L-type calcium channel current (ICa) by fendiline, a diphenylalkylamine type of calcium channel blocker was investigated on guinea-pig ventricular myocytes by use of the whole-cell patch-clamp technique....
général - core.ac.uk - PDF: www.pubmedcentral.nih.gov
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Fendiline enhances the cytotoxic effects of therapeutic agents on pdac cells by inhibiting tumor-promoting signaling events: a potential strategy to combat pdacThe L-type calcium channel blocker fendiline has been shown to interfere with Ras-dependent signaling in K-Ras mutant cancer cells....
général - core.ac.uk - PDF: www.mdpi.com


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