Dictionnaire français - anglais

santé - iate.europa.eu
Hormesis pervasiveness and its potential implications for pharmaceutical research and development... The use of techniques and technology, including high through-put screening, micro-dosing or phase 0 studies, pharmacometrics and adaptive trial design in the clinic, are proposed to illustrate how acknowledging the potential impact of hormesis throughout different stages of drug discovery and development,...
santé / technologie et réglementation technique / politique de coopération - core.ac.uk - PDF: www.pubmedcentral.nih.gov
essai clinique adaptatif
santé - iate.europa.eu
L'invention concerne un procédé et un système pour centraliser la gestion des données dans un essai clinique adaptatif ou autre procédé adaptatif conduit sur une pluralité de sites géographiquement distants.

A method and system are described for centrally managing data in an adaptive clinical trial or other adaptive process that is conducted at a plurality of geographically remote sites.

informatique et traitement des données - wipo.int
L'objectif est d'évaluer cliniquement l'utilisation de TTX-MC138 chez l'homme dans le cadre d'un essai clinique adaptatif et de traiter avec succès les patients atteints d'un cancer de stade IV.

The goal is to clinically assess the use of TTX-MC138 in humans in an adaptive clinical trial design, and to successfully treat patients with Stage IV cancer.

général - CCMatrix (Wikipedia + CommonCrawl)
Future vision for the quality assurance of oncology clinical trials... Information, including imaging, pathology, molecular biology, radiation oncology, surgery, systemic therapy and patient outcome data needs to be integrated into the clinical trial charter using adaptive clinical trial mechanisms for design of the trial....
général - core.ac.uk - PDF: doaj.org
Balancing learning and economies of scale: the case of adaptive clinical trialsPrior to the start of an adaptive clinical trial, demand for an investigational drug can be highly uncertain....
Optimizing interim analysis timing for bayesian adaptive commensurate designs... Bayesian adaptive clinical trial designs offer thepossibility of increased statistical efficiency, reduced development cost andethical hazard prevention via their incorporation of evidence...
 PDF: arxiv.org
Research open access the stroke hyperglycemia insulin network effort (shine) trial: an adaptive trial design case studyAdministration (FDA) to explore how adaptive clinical trial design might improve the evaluation of drugs and medical devices....
 PDF: ftp:
Biomarker informed adaptive clinical trial designs... Hence, considerable interest has been drawn towards the biomarker informed adaptive clinical trial designs....
essai clinique adaptatif
santé - iate.europa.eu

Publications scientifiques

How adaptive trial designs can increase efficiency in psychiatric drug development: a case studyThis paper uses a recently completed study to illustrate how adaptive trial designs can increase efficiency of psychiatric drug development....
général - core.ac.uk - PDF: www.pubmedcentral.nih.gov
Can emergency medicine research benefit from adaptive design clinical trials?Background: Adaptive design clinical trials use preplanned interim analyses to determine whether studies should be stopped or modified before recruitment is complete....
général - core.ac.uk - PDF: eprints.whiterose.ac.uk
Development of a bayesian response-adaptive trial design for the dexamethasone for excessive menstruation study.It is often unclear what specific adaptive trial design features lead to an efficient design which is also feasible to implement....
général - core.ac.uk - PDF: researchonline.lshtm.ac.uk
A practical guide to pre-trial simulations using sas and winbugs for bayesian response-adaptive trial designsIt is often unclear what specific adaptive trial design features lead to an efficient design which is also feasible to implement....
général - core.ac.uk - PDF: researchonline.lshtm.ac.uk

Synonymes et termes associés français

Traductions en contexte français - anglais

Il est sans aucun doute possible d'opter pour un essai clinique adaptatif de phase II et III.

Surely an Adaptive Phase II/III trial can be adopted.

général - CCMatrix (Wikipedia + CommonCrawl)
En plus des 24 patients qui participent déjà à cet essai clinique adaptatif à doses variées, 16 autres patients seront recrutés, dont au moins huit âgés entre 6 et 14 ans.

In addition to the 24 patients already enrolled in this adaptive-design, dose-ranging study, an additional 16 patients will be enrolled, with at least eight being between the ages of 6 and 14.

général - CCMatrix (Wikipedia + CommonCrawl)


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