Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ros1-translocated lung cancer ... Our driving hypothesis was that one of these multi-targeted tyrosine kinase inhibitors (TKIs) would have antiproliferative activity against ROS1 translocated non–small-cell lung cancer (NSCLC).Methods:We...
Ranging behaviour of adders (vipera berus) translocated from a development site... In 2014, a population of adders (Vipera berus) was translocated from a development site in Essex, UK....
The cationic cluster of group iva phospholipase a2 (lys488/lys541/lys543/lys544) is involved in translocation of the enzyme to phagosomes in human macrophages... In transfected cells a catalytically active EGFP-cPLA2α translocated to the phagocytic cup, which was corroborated by frustrated phagocytosis experiments utilizing immunoglobulin G-coated plates....
Cell biological approaches... Rho activator is translocated to the presumptive furrow region through microtubules, then, Rho is accumulated and activated there leading to myosin II contractility for furrowing....
