A novel cystacycline derivative which has an excellent effect of promoting the differentiation of neurons and is useful as a remedy for central nervous system disorders, a remedy for peripheral nerve disorders, etc.
Disclosed is a neuronal differentiation inhibitor which comprises at least one peptide capable of inhibiting or controlling the neuronal differentiation of at least one cell capable of being differentiated into a neuronal cell.
Collagen I and IV supported neuronal differentiation and extensive glial differentiation individually and in combination.
The present invention provides a neuronal differentiation promoter for a neural stem cell, which comprises a p38 inhibitor.
Involved in the initiation of neuronal differentiation.
The present invention also provides a method for promoting the neuronal differentiation of a neural stem cell, which comprises culturing the neural stem cell in the presence of a p38 inhibitor.
Methods for detecting neural regeneration, neural proliferation, neural differentiation, neurite outgrowth and neural survival can be used to develop other neurally active agents.
Differentiation towards a neural fate, and away from a non-neural fate, is promoted by activation of Notch signalling in ES cells and then transferring the cells into neural differentiation protocols.
Media for neural differentiation comprises a Notch activator, e.g. a notch ligand that can be clustered.
The effects range from neuronal differentiation to protection against cerebral ischemia.
The effects range from neuronal differentiation to protection against cerebral ischemia.
The effects range from neuronal differentiation to protection against cerebral ischemia3.
The effects range from neuronal differentiation to protection against cerebral ischemia3.
The effects range from neuronal differentiation to protection against cerebral ischemia.
The present invention relates to the activation of the CD95L/CD95 system for inducing neuronal differentiation in vitro and in vivo and the use of CD95L compositions to effect differentiation.
Methods are provided for increasing neuronal differentiation of neuronal stem cells using antibodies that bind lysophosphatidic acid (LPA).
The effects range from neuronal differentiation to protection against cerebral ischemia3.
The effects range from neuronal differentiation to protection against cerebral ischemia.
Disclosed is a method for screening a neuronal differentiation inducer by using a ubiquitin C-terminal hydrolase I (UCH-L1).
The present invention relates to compositions and methods for culturing stem cells, such that neuronal differentiation can be achieved.
Neurosciences (neuronal and neuroendocrine differentiation, neurosecretion; neuroendocrine tumours and glial tumours; Alzheimer's disease; perinatal neurological handicaps).
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