Structural model for phenylalkylamine binding to l-type calcium channels*... We have built a KvAP-based model of LTCC and used Monte Carlo energy minimizations to dock devapamil, verapamil, gallopamil, and other PAAs....
Molecular pharmacology, 34:172-179 potential-dependent allosteric modulation of 1,4-dihydropyridine binding by d-(cis)-diltiazem and (±)-verapamil in living cardiacWe have studied allostenc effects of the Ca channel blockers d-(cis)-diltiazem, (±)-verapamil, and (S)- and (R)-devapamil on the specific binding of the 1,4-dihydropyridine derivative (+)-[3H]PN 200-1 1 0 to intact tissue cultured rat heart cells....
The ivs6 segment of the l-type calcium channel is critical for the action of dihydropyridines and phenylalkylamines.... These mutations only slightly affected the blocking efficacy of mibefradil and the phenylalkylamine devapamil....
Calcium channel block by (-)devapamil is affected by the sequence environment and composition of the phenylalkylamine receptor site ... Association and dissociation rates of (-)devapamil were compared for a highly PAA-sensitive L-type Ca2+ channel chimera (Lh) and various class A Ca2+ channel mutants....
