These are made by dealkylating corresponding 6-alkoxy-9-methyl-10-substituted echibolines, thereby converting the 6-alkoxy group to a 6-hydroxy group, especially using boron tribromide as dealkylating reagent.

Metabolism of anastrozole occurs by N-dealkylation, hydroxylation and glucuronidation.

The elimination is predominantly hepatic by glucuronidation and N-dealkylation.

Metabolism of Anastrozole occurs by N –dealkylation, hydroxylation and glucuronidation.

Rotigotine is metabolised by N-dealkylation as well as direct and secondary conjugation.

The dealkylation-transalkylation system includes dealkylation, non-aromatic product gas separations and transalkylation stages.

Firocoxib is metabolised predominantly by dealkylation and glucuronidation in the liver.

The α-keto bisphosphonate esters can be converted to the corresponding acids by acid hydrolysis or mild silyldealkylation.

Further disclosed is the preparation of 2,3-dihydroxy benzonitrile by dealkylation of 2,3-dialkoxy benzonitrile using suitable aluminum salt-amine complex.

Domperidone undergoes rapid and extensive hepatic metabolism by hydroxylation and N-dealkylation.

Domperidone undergoes rapid and extensive hepatic metabolism by hydroxylation and N-dealkylation.

The present disclosure also provides improved processes for preparing semi-synthetic opioids that incorporate the disclosed methods for N-dealkylation of tertiary amines.

Domperidone undergoes rapid and extensive hepatic metabolism by hydroxylation and N-dealkylation.

68953-80-0 Benzene, mixed with toluene, dealkylation product

N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide.