The 2-methylenethiazoles are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base.

The thiophenes are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base.

The present invention generally relates to a process for preparing 2,2- dibromomalonamide from 2,2-dibromo-3-cyanoacetamide.

A cyanoacetamide derivative represented by formula (I), a plant disease control agent containing the same as the active ingredient, and an intermediate for use in producing the same.

The process includes reacting 2-cyanoacetamide with sodium methoxide followed by condensation with ethyl 2-methylacetoacetate in methanol to give the sodium salt of 2,6-dihydroxy-4,5-dimethyl-3-pyridinecarbonitrile.