It may also be necessary to verify whether the overall survival data in the post-authorisation phase is discordant with or confirmative of the outcome of the surrogate endpoint.
In certain cases, average telomere length is a surrogate marker for a telomere-associated disease or disorder.
More specifically, the invention relates to the Lupac surrogate marker, which corresponds to a fusion between luciferase and the puromycin N-acetyl transferase.
The relation between the surrogate end point and the disease should have a biologically plausible explanation
However, this surrogate outcome (as well as the previously employed biochemical and histologic ones) has never been validated," the authors write.
However, this surrogate outcome (as well as the previously employed biochemical and histologic ones) has never been validated.
The method is useful in conjunction with established therapies such as thrombolytic therapy, and is particularly useful as a surrogate end point in clinical trials of new potential therapies.
This invention relates to industrial production of proteins.
Nobel Laureates are used as a proxy to study at what age scientists produce their most groundbreaking work.
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