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Cl- secretion induced by bile salts. a study of the mechanism of action based on a cultured colonic epithelial cell line.... This apical effect on electrolyte transport was associated with an abrupt increase in the permeability of the monolayer....

général - core.ac.uk - PDF: www.pubmedcentral.nih.gov

apical endpoint

santé - iate.europa.eu

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A tox21 approach to altered epigenetic landscapes: assessing epigenetic toxicity pathways leading to altered gene expression and oncogenic transformation in vitro... In the context of human cell transformation models, these in vitro pathway measurements ensure high biological relevance to the apical endpoint of cancer....

santé - core.ac.uk - PDF: doaj.org

Publications scientifiques

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Assessing uncertainty in read-across: questions to evaluate toxicity predictions based on knowledge gained from case studies... The main sources of uncertainty were established and divided into four main categories: i) the regulatory use of the prediction, ii) the data for the apical endpoint being assessed, iii) the readacross argumentation, and iv) the similarity justification....

général - core.ac.uk - PDF: researchonline.ljmu.ac.uk

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In vitro rna-seq-based toxicogenomics assessment shows reduced biological effect of tobacco heating products when compared to cigarette smoke... battery of regulatory tests used to evaluate the risk of novel tobacco products such as heated tobacco products (THPs) presents some limitations including a bias towards the apical endpoint tested, and limited information on the mode of action....

général - core.ac.uk - PDF: link.springer.com

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Biodegradation of a mixture of benzophenone, benzophenone-3, caffeine and carbamazepine in a laboratory test filter... toxicity of samples which were undergone different biodegradation phases was assessed with two standard laboratory tests with apical endpoint – acute toxicity test with Daphnia magna (immobilisation) and bioluminescence inhibition with Vibrio fisheri....

général - core.ac.uk - PDF: doaj.org

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Predicting fish acutetoxicity using a fish gill cellline-based toxicity assayThe OECD test guideline 203 for determination of fishacute toxicityrequires substantial numbers of fish and uses death as an apical endpoint....

général - core.ac.uk - PDF: figshare.com